Genetic liability to osteoarthritis may be greater in women than men

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Abstract
EDITOR,—Tim D Spector and colleagues report a study of genetic influences on osteoarthritis in monozygotic and dizygotic female twins.1 They conclude that their results show a clear genetic effect for radiographic osteoarthritis of the hand and knee in women (ranging from 39% to 65%) independent of known environmental or demographic confounders. In his commentary on the paper John Hopper states that these figures must be considered to be an upper bound of the genetic influence.1 In a questionnaire sent to the Finnish twin cohort …