Infants of diabetic mothers: Late normalization of fetal cyclic motility persists after birth
- 1 July 1988
- journal article
- research article
- Published by Wiley in Developmental Psychobiology
- Vol. 21 (5) , 477-490
- https://doi.org/10.1002/dev.420210507
Abstract
The prenatal development of cyclic motility (CM) in the human is disrupted by maternal diabetes, but appears normal by the end of gestation. To determine whether birth and adaptation to postnatal life reveal new or persisting abnormalities in CM, 24 newborn infants of insulin‐dependent diabetic mothers (IDMs) and 24 normal newborns were studied for 2–4 hr in a controlled environment. Spectral analysis of spontaneous movement revealed that CM was common in both groups. Measures of its cyclic organization in each state did not differ between IDMs and controls. State differences were the same in the two groups, and replicated the pattern found in a previous study of normal newborns. For IDMs, there were no differences associated with neonatal evidence of increased glucose supply in utero (macrosomia, postnatal hypoglycemia), or with determinations of prenatal maternal hyperglycemia. IDMs had also been studied as fetuses, and the pattern of continuity and change in CM across birth replicated the pattern previously reported for normal fetuses. The results suggest that the development and control of CM is buffered from the prenatal metabolic insults suffered by IDMs, and support speculations that cyclic activation is a general and robust property of the developing motor system in the human.This publication has 29 references indexed in Scilit:
- Cyclic motor activity in the fetal rat (Rattus norvegicus).Journal of Comparative Psychology, 1988
- Human cyclic motility: Fetal-Newborn continuities and newborn state differencesDevelopmental Psychobiology, 1987
- The development of cyclic motility in fetuses of diabetic mothersDevelopmental Psychobiology, 1986
- Cyclic motor activity in the human fetus after midgestationDevelopmental Psychobiology, 1985
- Newborn infants of diabeticsInfant Behavior and Development, 1984
- Behavior of newborns of diabetic mothersInfant Behavior and Development, 1982
- A simplified score for assessment of fetal maturation of newly born infantsThe Journal of Pediatrics, 1979
- Brain and Behavioural Maturation in Newborn Infants of Diabetic Mothers1– Part I: Nerve conduction and EEG patterns2Neuropediatrics, 1969
- Brain and Behavioural Maturation in Newborn Infants of Diabetic Mothers1– Part II: Sleep cycles2Neuropediatrics, 1969
- Intrauterine growth of live-born Caucasian infants at sea level: Standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeksPublished by Elsevier ,1969