Morbid Anatomy, Histopathology, and Histopathogenesis of Forestomach Carcinoma in Mice Fed Carcinogenic Hydrocarbons in Oil Emulsions

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Abstract
A study of squamous cell carcinoma of the forestomach in mice given aqueous olive oil or mineral oil emulsions containing 20-methylcholanthrene of 1,2,5,6-dibenzanthracene instead of drinking water. Of 425 exptl. mice, 71 developed carcinoma (of these 35 showed secondary extension to adjacent organs and structures, implantation, or metastasis). No sarcomas developed. Many exptl. mice exhibited acanthosis, hyperkeratosis, papilloma, and nearocarcinoma of forestomach mucosa. The role of these changes in the neoplastic process is discussed. Control mice (142) received no carcinogen; some were given tap water, some dist. water, and the remainder an aqueous soln. of Aerosol, or aqueous emulsions of olive oil or mineral oil with or without Aerosol instead of drinking water. Acanthosis, hyperkeratosis, and papilloma appeared in many control mice. These changes were most pronounced in animals ingesting mineral oil emulsions. No control mice developed nearocarcinoma or carcinoma. The morphological aspects of a lesion occurring in exptl. mice and designated the umbilicate lesion are described. Criteria were adopted for diagnosis of squamous cell carcinoma and for distinguishing early neoplastic lesions from benign hyper-plastic changes.