Direct Inhibitory Effect of Dexamethasone on Steroidogenesis of Human Adrenalin Vivo
- 1 May 1979
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 48 (5) , 861-863
- https://doi.org/10.1210/jcem-48-5-861
Abstract
A rapid ACTH test was used to investigate the direct effect of glucocorticoid on the steroidogenesis by the adrenal cortex in man. The plasma cortisol response to 250 μg iv synthetic a-ACTH-(l–24) (Cortrosyn) was determined in normal subjects pretreated with 2 and 12 mg dexamethasone. The 15- and 30-min increments in plasma cortisol levels in response to ACTH injection after pretreatment with 12 mg dexamethasone were significantly suppressed compared to values obtained after pretreatment with 2 mg dexamethasone. The present study suggests that there is a direct inhibitory effect of glucocorticoid on adrenocortical steroidogenesis in man.Keywords
This publication has 1 reference indexed in Scilit:
- INFLUENCE OF CORTISOL ON TROPHIC AND CORTICOSTEROIDOGENIC ACTIONS OF ADRENOCORTICOTROPHIN ON FOETAL ADRENALSJournal of Endocrinology, 1976