Neue β‐Lactam‐Antibiotika. Über die Darstellung von N‐Acylderivaten der 7‐Amino‐ceph‐3‐em‐4‐carbonsäure. Modifikationen von Antibiotica, 6. Mitteilung [1]
- 31 January 1972
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 55 (2) , 423-429
- https://doi.org/10.1002/hlca.19720550212
Abstract
Oxydation of 2 with iodine followed by acylation leads to β‐lactamdisulfides of type 3. Compounds 3 can be transformed into alcohols 4 by reductive alkylation with ethylenoxide and zinc/acetic acid. Compounds 4 are used as starting materials for the synthesis of N‐acylderivatives 12 of 7‐amino‐ceph‐3‐em‐4‐carboxylic acid (D).Keywords
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- Neue β‐Lactamsysteme aus Penicillinen. Modifikationen von Antibiotika, 5. Mitteilung [1]Helvetica Chimica Acta, 1972
- The Total Synthesis of Cephalosporin C1Journal of the American Chemical Society, 1966