Hazards of oral anticoagulants during pregnancy

Publisher Website
Google Scholar
Abstract
Prenatal exposure to oral anticoagulants during [human] pregnancy may result in defective fetal development or life-threatening hemorrhage. Fetal exposure during the first 8 wk of pregnancy may cause abnormal development of the facial structures, hypoplastic digits, stippled epiphyses and mental retardation. Midtrimester exposure may result in optic atrophy, faulty brain growth and developmental retardation. Third trimester exposure may produce fetal anticoagulation, predisposing the infant to life-threatening hemorrhage in the perinatal period. Anticoagulation with heparin Na does not provide a clearly safe alternative, since this therapy is associated with excessive fetal loss.

This publication has 2 references indexed in Scilit: