Immune Profile of Infectious Bursal Disease (IBD). II. Effect of IBD Virus on Pokeweed-Mitogen-Stimulated Peripheral Blood Lymphocytes of Chickens
- 30 June 1980
- journal article
- research article
- Published by JSTOR in Avian Diseases
- Vol. 24 (3) , 734-742
- https://doi.org/10.2307/1589809
Abstract
Pokeweed mitogen-stimulated peripheral blood lymphocytes from chickens infected with infectious bursal disease virus (IBDV) at 1 day and 3 wk of age, together with those from uninfected age-matched control chickens, were examined at weekly intervals for their capacity to undergo in vitro terminal differentiation. The study included the determination of cytoplasmic Ig (CIg)-containing peripheral blood lymphocytes and those bearing the surface membrane Ig (SmIg) cells to detect any defect in Ig synthesis and secretion, respectively. There was a highly significant and pronounced progressive depletion of CIg-containing cells in chickens infected at 1 day of age. IBDV affected the immature or precursor B cells to a far greater extent than mature B lymphocytes.This publication has 1 reference indexed in Scilit:
- Separation and analysis of differentiating B lymphocytes from mouse spleensCellular Immunology, 1976