This report details a case of carcinoma in a thyroglossal cyst. Report of Case A 52-year-old male was seen at our Head and Neck Clinic on Nov. 22, 1960, complaining of a "lump in the neck," which had been present for 2 years. The swelling had been small when first noticed by the patient, and several months later it had almost disappeared. Three months before consultation in our Clinic, he noticed that the nodule had suddenly increased in size. No accompanying symptoms had been observed by the patient. On examination, a 3×2 cm. smooth and firm mass, which moved up and down when the patient was swallowing, was encountered in the midline of the neck at the level of the hyoid bone but extending more inferiorly than superiorly. No enlarged lymphatic glands were found in the cervical area. A clinical diagnosis of thyroglossal cyst was made. Surgery was performed on