Biosynthesis of the abietane type diterpene ferruginol in cell cultures of Salvia miltiorrhiza: synthesis of (15S)- and (15R)-[16-2H1]12-O-methylferruginol by enzymatic resolution of 12-O-methyl-16-hydroxyferruginol and stereochemistry of 1,2-methyl migration in the formation of the isopropyl group
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 108-110
- https://doi.org/10.1039/c39890000108
Abstract
The signals for the pro(R) and pro(S) methyl groups of the isopropyl group, in the 13C{1H} n.m.r. spectrum of 12-O-methylferruginol, have been assigned by the synthesis of the title compounds and the stereochemistry of 1,2-methyl migration for biosynthesis of the abietane skeleton of ferruginol has been established.Keywords
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