Horizontal transmission of hepatitis b virus infection in household contacts, pune, india

Publisher Website
Google Scholar
Abstract
The study was undertaken to detect the risk of infection, if any, among 193 household contacts of 40 hospitalised hepatitis patients (group I) with hepatitis B surface antigen (HBsAg) in their blood. As a control group, 103 household contacts of 27 hospitalised hepatitis patients who were negative for HBsAg (group II) were investigated. The family contacts of the former group had a significantly higher prevalence of HBV infection than those of the latter group (P < .001). Significant differences were observed both in the prevalence of HBsAg (P < .05) and antibody to HBsAg (anti-HBs) (P < .025) between the two groups. IgM antibody to hepatitis B core antigen (anti-Hbc-IgM) was detected in 32 out of the 39 (82%) sera tested from the patients of group I with HBsAg. A statistically significant difference (P < .005) of HBV prevalence was also found in the contacts of these 32 patients suffering from acute hepatitis B as compared to the contacts of the patients of group II. Overall, the children of the first group showed a significantly higher prevalence of HBsAg as compared to the second group. All the children with HBsAg were positive for HBeAg also, but were negative for anti-HBc-IgM. Anti-HBs was detected in a significantly larger number of adult females. Spouses were found to be affected more than other relatives. A significant difference (P < .025) was noted in the number of families having HBV markers in group I (80.0%) as compared to those in group II (48.1%). In group I, contacts of male patients had a significantly higher (P < .025) prevalence of HBV infection than those of the female patients (46.4% vs 29.3%).