DEOXYADENOSINE METABOLISM AND TOXICITY IN CULTURED L5178Y CELLS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (9) , 3013-3017
Abstract
The growth of cultured [mouse leukemia] L5178Y cells is inhibited by relatively low concentrations of deoxyadenosine in the presence of deoxycoformycin, an inhibitor of adenosine deaminase. Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhibition in DNA synthesis, accumulation of cells in G1 or early S phase, a continuation in RNA synthesis, and increasing cell volume. The intracellular concentrations of purine and pyrimidine ribonucleoside phosphates remain essentially unchanged. The significant changes in the intracellular deoxynucleoside triphosphate pools are an increase in deoxyadenosine triphosphate and a decrease in deoxycytidine triphosphate.

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