The Effect of Insecticides and Other Toxic Substances Upon the Reduced Glutathione of Periplaneta americana1

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Abstract
Pb diacetate, As trioxide, dibasic Na arsenate, Cu chloride, and Fe chloride exert inhibitory action upon the reduced glutathione (GSH) of the American roach, whereas chlordan, p p'' DDT, parathion, nicotine, pyrethrins, rotenone, toxaphene, Na fluoride, and benzene hexachloride are without effect. Injn. of GSH protects against the toxic effects of As trioxide. Roaches which receive sub-lethal doses of As regain a normal GSH level within 24-48 hrs. Although the mode of action does not appear to differ between the sexes, equivalent amts. of As inhibit up to 4 times as much GSH in the male as in the female. Results suggest that As and Cu are similar with respect to insecticidal mode of action, whereas that of Fe is quite different.

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