Behavioral effects of "phenylketonuria" in rats.
- 1 January 1967
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 57 (1) , 102-106
- https://doi.org/10.1073/pnas.57.1.102
Abstract
The results of the 1st experiment, together with those of all experiments with rats, form a compelling body of evidence that no rat "PKU [phenylketonuric] preparation" yet devised adequately simulates the irreversible intellectual impairments seen in most late-detected PKU children. The results of the last 2 experiments indicate that the detrimental behavioral effects of chronic overloads of P [L-phenylalanine] are attenuated by melatonin and specifically related to some aspect of P overloading of the rat.This publication has 18 references indexed in Scilit:
- A comparison of behavioral tests for measuring the effects of phenylketonuria in ratsLife Sciences, 1966
- Phenylketonuria in a Woman of Normal Intelligence and Her ChildNew England Journal of Medicine, 1966
- Phenylketonuria in Rats: Reversibility of a Behavioral DeficitScience, 1966
- Dosage parameters of a behavioral deficit associated with phenylketonuria in rats.Journal of Comparative and Physiological Psychology, 1966
- Behavioural Deficit in the Rat induced by feeding PhenylalanineNature, 1965
- FREE AMINO ACIDS IN FOETAL RAT BRAINJournal of Neurochemistry, 1965
- Effects on rat offspring of maternal phenylalanine diet during pregnancyJournal of Psychiatric Research, 1965
- Experimental attempts to produce phenylketonuria in animals: A critical review.Psychological Bulletin, 1965
- Maternal PhenylketonuriaNew England Journal of Medicine, 1963
- ATYPICAL PHENYLKETONURIA IN SISTERS WITH NORMAL OFFSPRINGThe Lancet, 1961