Chronic inflammatory demyelinating polyneuropathy caused by HIV infection in a patient with asymptomatic CMT 1A
- 1 September 2000
- journal article
- case report
- Published by Wiley in Journal of the Peripheral Nervous System
- Vol. 5 (3) , 158-162
- https://doi.org/10.1046/j.1529-8027.2000.00014.x
Abstract
It is well known that patients with Charcot‐Marie‐Tooth (CMT) disease are liable to present with episodes of cortisone‐responsive demyelination, and a superimposed inflammatory component has been suggested. We report a patient who presented with a chronic inflammatory demyelinating polyneuropathy due to a recent HIV infection, which revealed a previously asymptomatic CMT 1A disease documented by identification of the characteristic duplication on the p11.2 region of chromosome 17. The inflammatory process was characterized by pathologic findings on a superficial peroneal nerve biopsy, and the patient improved significantly after corticotherapy. This report gives support to the hypothesis of a genetic susceptibility to inflammatory demyelinating processes in certain CMT kindreds.Keywords
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