The vasopressin response to microinjections of norepinephrine into the brain of the conscious pig

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Abstract
The possibility that the amygdala influences the release of vasopressin was raised by the observation that electrical stimulation of this area results in vasopressin release in the conscious animal. Therefore the effect on vasopressin concentrations was studied by microinjections of norepinephrine into the amygdala of the conscious miniature pig. The studies were performed on castrated male and female pigs with chronically implanted cannulae in the brain and in the external jugular vein. Lysine vasopressin concentrations were determined using a specific sensitive radioimmunossay. Microinjections of 1 .mu.l 0.12 M sodium chloride were without effect. Injections of norepinephrine in the dose range 10-4-10-10 M had no effect in the male animal but a significant suppression response could be obtained in the females.