The Swelling of Core Tablets During Aqueous Coating I: A Simple Model Describing Extent of Swelling and Water Penetration for Insoluble Tablets Containing a Superdisintegrant
A simple mathematical model was established to describe changes of tablet thickness due to swelling and water penetration during aqueous coating process. The model was illustrated by a simple linear equation, i.e.; D = -(α/(l+ε))l1,+(α/(l+ε))l0; where D, l0,11, α and ε are the depth of water penetrating into tablets, initial tablet thickness, the remaining dried core tablet thickness, swelling and porosity parameters, respectively. The data from dicalcium phosphate dihydrate(Ditab) tablets containing a super-disintegrant may be fitted into the model showing significant statistical correlation. The model was valid for describing the extent of tablet swelling and water penetration during aqueous coating.