Chemoenzymatic Synthesis of Rivastigmine via Dynamic Kinetic Resolution as a Key Step
- 26 March 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 75 (9) , 3105-3108
- https://doi.org/10.1021/jo9027374
Abstract
A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (−)-rivastigmine was obtained from commercially available 3′-hydroxyacetophenone via five steps in overall 57% yield.Keywords
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