Coronary Vasoconstriction Caused by Indomethacin

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Abstract
To the Editor: In the November 12 issue, Friedman et al. 1 show that indomethacin produces coronary vasoconstriction. The authors used a large intravenous dose that they theorized would produce a blood level of 5 μg per milliliter, which they say is similar to that obtained with long-term oral therapy (25 to 50 mg three times a day). Yet Figure 5 of the paper they cite for this comparison2 reports a blood level of only 0.3 μg per milliliter. Furthermore, the authors used an intravenous dose that was 40 per cent greater, and they made their measurements 33 per cent earlier. . . .