HPLC Determination of Beclomethasone Dipropionate and Its Degradation Products in Bulk Drug and Pharmaceutical Formulations
- 1 July 1995
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 28 (9) , 1655-1663
- https://doi.org/10.1080/00032719508002772
Abstract
An HPLC method for the simultaneous determination of beclomethasone dipropionate and its principal degradation products has been developed. The only sample treatment necessary for the analysis is its dilution with methanol. The practical detection limit is 0.02 % of each impurities in terms of the parent drug, whereas the absolute limit of detection is 2.5 ng of each injected compound. The method has been applied to the analysis of both pharmaceutical formulations and samples of bulk drug.Keywords
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