Is Contrast-related Vasodilatation after Intra-coronary Iodixanol and Iopromide In Vivo Endothelium-dependent?

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Abstract
Aims: Goals of the study were the assessment of the correlation between flow-dependent and contrast-related vasodilatation, comparison of iodixanol to iopromide and evaluation of the impact of plaque on vasodilatation in coronary arteries. Methods and Results: A controlled randomized paired cross-over comparison between iodixanol (320 mg I.ml -1 ) and iopromide (300 mg I.ml −1 ) was performed in 10 consecutive patients. Vessel area (Visions Five-64 F/X™ intra-vascular ultrasound-catheter, Endosonics ® and blood flow velocity measurements (0.014 inches Doppler guide wire, Cardiometrics ® ) were recorded simultaneously at an identical position, at baseline, after i.c. bolus injection of 10 ml physiologic saline (flow-dependent vasodilatation), and after application of contrast agent 1 and contrast agent 2 as randomized. The action of iodixanol and iopromide on the vascular wall did not differ and was equal to local flow-dependent vasodilatation induced by a saline bolus (correlation 0·95– 0·98). The increase in local luminal area after injection of saline, iodixanol and iopromide in morphologically normal vessels (∼2·5 mm 2 ) was absent in atherosclerotic segments. Both contrast agents and saline demonstrated a nearly identical flow increase. Conclusion: If iodixanol or iopromide are used as contrast agents, contrast-related vessel area increase in vivo seems to be endothelium-dependent.

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