Regulation of Leukocyte Migration Across Endothelial Barriers by ECTO-5′-Nucleotidase-Generated Adenosine
- 3 July 2008
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 27 (6-7) , 755-760
- https://doi.org/10.1080/15257770802145678
Abstract
CD73-deficient mice are valuable for evaluating the ability of CD73-generated adenosine to modulate adenosine receptor-mediated responses. Here we report the role of CD73 in regulating lymphocyte migration across two distinct barriers. In the first case, CD73-generated adenosine restricts the migration of lymphocytes across high endothelial venules (HEV) into draining lymph nodes after an inflammatory stimulus, apparently by triggering A2B receptors on HEV. Secondly, CD73 promotes the migration of pathogenic T cells into the central nervous system during experimental autoimmune encephalomyelitis. Experiments are in progress to determine whether this effect is also adenosine receptor-mediated and to identify the relevant adenosine receptor.Keywords
This publication has 6 references indexed in Scilit:
- Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin–mediated cell–cell contactsThe Journal of Experimental Medicine, 2006
- Nepmucin, a novel HEV sialomucin, mediates L-selectin–dependent lymphocyte rolling and promotes lymphocyte adhesion under flowThe Journal of Experimental Medicine, 2006
- Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during HypoxiaThe Journal of Experimental Medicine, 2004
- Opposite effect of cAMP signaling in endothelial barriers of different originAmerican Journal of Physiology-Cell Physiology, 2004
- CD73 Engagement Promotes Lymphocyte Binding to Endothelial Cells Via a Lymphocyte Function-Associated Antigen-1-Dependent MechanismThe Journal of Immunology, 2000
- Adenosine receptorsNeuropharmacology, 1995