Tumour Necrosis Factor-α and Lipopolysaccharide Enhance Interferon-Induced Tryptophan Degradation and Pteridine Synthesis in Human Cells

Publisher Website
Google Scholar
Abstract
The capacity of recombinant interferon-.alpha., -.beta. and -.gamma., of bacterial lipopolysaccharide and of recombinant tumour necrosis factor-.alpha. to induce indoleamine 2,3-dioxygenase and synthesis of pteridines was studied in human peripheral blood mononuclear cells, human macrophages and normal dermal fibroblasts. The action of interferon-.alpha. and -.beta. on macrophages was supported by lymphocyte factors as indicated by the effect of these mediators in the absence or presence of lymphocytes. Tumour necrosis factor-.alpha. alone was ineffective in peripheral blood mononuclear cells and macrophages, but it significantly increased the action of all three interferon species on macrophages and fibroblasts. Lipopolysaccharide directly affected macrophages or dermal fibroblasts and enhanced the effect of interferon-.gamma.. However, in the presence of lymphocytes, the action of lipopolysaccharide was mediated via interferon-.gamma.

This publication has 15 references indexed in Scilit: