Abstract
The possible roles of intra-and extracellular carbonic anhydrase in cyanobacterial and algal photosynthesis are discussed. Carbonic anhydrase is likely to have a role in photosynthetic (C3 biochemistry) inorganic C acquisition by most algae under their natural growth conditions. The inorganic C substrate, intracellular location, metabolic roles and taxonomic distribution of non-photosynthetic carboxylases of algae and cyanobacteria are reviewed. From the quantitative role of these (cytosolic phosphoenolpyruvate carboxylase in red and green algae; acetyl CoA carboxylase predominantly in plastids in all taxa) it is likely that carbonic anhydrase is needed to account for the expressed activity of these HCO3− using enzymes under natural conditions when CO2 is the inorganic C substrate supplied to the organism.

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