Serum Protein and Glycoprotein Alteration in Swine with Experimental Arthritis.

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Abstract
The serum proteins and glycoproteins of swine were studied during the development of an experimental arthritis which follows recovery from Erysipelothrix infections. Total serum glycoprotein and seromucoid were quantitated by determination of bound hexose using the tryptophan method. Paper electrophoretic methods were used to study the distribution of bound carbohydrate among the various protein fractions. As in sera from humans with rheumatoid arthritis, elevated serum glycoprotein, seromucoid and serum globulins and lowered serum albumin concentrations were noted in swine sera during active phases of the disease. No serum [alpha]1-globulin was identified in swine sera. During remissions of experimental arthritis, serum glycoprotein levels decreased and the serum albumin increased. Cortisone treatment of animals with active arthritis produced clinical improvement accompanied by striking increases of albumin protein with decreases of seromucoid, serum gamma-globulin protein and gamma-globulin bound hexose concentrations.