Human muscle cells express a B7‐related molecule, B7‐H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
Open Access
- 15 August 2003
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 17 (13) , 1-16
- https://doi.org/10.1096/fj.03-0039fje
Abstract
B7-H1 is a novel B7 family protein attributed to costimulatory and immune regulatory functions. Here we report that human myoblasts cultured from control subjects and patients with inflammatory myopa...Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (Wi 1722/2-1, Lo 549/2-3)
- National Institutes of Health (CD97085)
This publication has 35 references indexed in Scilit:
- Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 InteractionThe Journal of Experimental Medicine, 2003
- The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune ResponsesAnnual Review of Immunology, 2002
- Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial CellsMicrocirculation, 2002
- PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2European Journal of Immunology, 2002
- The B7–CD28 superfamilyNature Reviews Immunology, 2002
- Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte ActivationThe Journal of Experimental Medicine, 2000
- Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis.Journal of Clinical Investigation, 1996
- T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells.The Journal of Experimental Medicine, 1995
- The immunobiology of muscleImmunology Today, 1994
- Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection.Journal of Clinical Investigation, 1993