Sporadic HEV hepatitis in Italy

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Abstract
Editor,—We read with great interest the paper of McCrudden et al concerning acute hepatitis E (HEV) in the UK ( (2000) Gut 46:732–3; [OpenUrl][1][PubMed][2][Web of Science][3] ). We agree wholeheartedly with the authors that this form of hepatitis is on the increase in industrialised countries. In Italy, the reported prevalence of anti-HEV IgG positivity ranges from 0.74% to 1.94%,1 although a recent study found a prevalence of 2.6% in one small town in central Italy.2 A value of 1.5% has been reported for the general adult population of the Republic of San Marino.3 We have recently observed two cases of acute hepatitis E with no evidence of any known risk factors. Case 1 . In September 1997, a 45 year old Italian woman (not pregnant) was … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bmedical%2Bvirology%26rft.stitle%253DJ%2BMed%2BVirol%26rft.aulast%253DZanetti%26rft.auinit1%253DA.%2BR.%26rft.volume%253D42%26rft.issue%253D3%26rft.spage%253D318%26rft.epage%253D320%26rft.atitle%253DHepatitis%2Btype%2BE%2Bin%2BItaly%253A%2Ba%2Bseroepidemiological%2Bsurvey.%2BStudy%2BGroup%2Bof%2BHepatitis%2BE.%26rft_id%253Dinfo%253Apmid%252F8006645%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=8006645&link_type=MED&atom=%2Fgutjnl%2F48%2F4%2F580.1.atom [3]: /lookup/external-ref?access_num=A1994MY34600020&link_type=ISI

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