A Comparative Analgesic Study of Propoxyphene, Fenoprofen, the Combination of Propoxyphene and Fenoprofen, Aspirin, and Placebo

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Abstract
Groups of 27 inpatients with moderate or severe postoperative, fracture or somatic pain were given single oral doses of propoxyphene napsylate (P), fenoprofen calcium (F), combinations of P and F, aspirin or a placebo. The increasing rank order for effectiveness, with doses in mg, was placebo, P50, aspirin 650, F600, F50, P50 + F50, F200, P50 + F600, P50 + F200, P200 + F50, P200, P200 + F200 and P200 + F600. The overall analgesic response to P in this dose range (50-200 mg) increased linearly with increasing doses. The F response increased in proportion to the dose up to 200 mg; the overall response to 600 mg was not significantly different from that to 200 mg. P and F had additive analgesic effects. There were no drug-related adverse reports.

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