Estimation of Cerebral Blood Flow From Thermal Measurement
- 1 February 1995
- journal article
- Published by ASME International in Journal of Biomechanical Engineering
- Vol. 117 (1) , 74-85
- https://doi.org/10.1115/1.2792273
Abstract
A thermal method has been developed to quantify continuous perfusion changes with self-calibration. A dynamic, one-dimensional bio-heat transfer model of the thermal probe and tissue describes the system response to either continuous or transient heating. A nonlinear least-squares fit of the model to experimental data yields estimates of the baseline perfusion and other model parameters. With a partial analytical solution of the model, the optimal estimation procedure is two orders of magnitude more efficient than with a total numerical solution of the model system. Experimental data is used to estimate the operating relations between perfusion and the temperature measurement. A new procedure has also been presented to obtain the dynamic response of the system for continuous measurement of perfusion.Keywords
This publication has 30 references indexed in Scilit:
- Validation of Continuous Thermal Measurement of Cerebral Blood Flow by Arterial Pressure ChangeJournal of Cerebral Blood Flow & Metabolism, 1993
- A Combined Heat Clearance Method for Tissue Blood Flow MeasurementJournal of Biomechanical Engineering, 1991
- Optimal design of a thermistor probe for surface measurement of cerebral blood flowIEEE Transactions on Biomedical Engineering, 1990
- Computer-based system for continuous on-line measurements of tissue blood perfusionJournal of Biomedical Engineering, 1987
- Thermal Pulse Decay Method for Simultaneous Measurement of Local Thermal Conductivity and Blood Perfusion: A Theoretical AnalysisJournal of Biomechanical Engineering, 1986
- Simultaneous Determination of Local Cerebral Glucose Utilization and Blood Flow by Carbon-14 Double-Label Autoradiography: Method of Procedure and Validation Studies in the RatJournal of Cerebral Blood Flow & Metabolism, 1986
- Theory and Experiment for the Effect of Vascular Microstructure on Surface Tissue Heat Transfer—Part II: Model Formulation and SolutionJournal of Biomechanical Engineering, 1984
- The Simultaneous Measurement of Thermal Conductivity, Thermal Diffusivity, and Perfusion in Small Volumes of TissueJournal of Biomechanical Engineering, 1984
- Pulse-Decay Method for Measuring the Thermal Conductivity of Living TissuesJournal of Biomechanical Engineering, 1981
- Heat and matter distribution in body tissues and the determination of tissue blood flow by local clearance methodsJournal of Theoretical Biology, 1962