Elimination of prostacyclin (PGI2) and 6-oxo-PGF1α in anaesthetized dogs

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Abstract
The plasma concentration of 6-oxo-PGF1α was measured by radioimmunoassay after constant rate infusion of 6-oxo-PGF1α or prostacyclin (PGI2) into anaesthetized dogs. A steady-state plasma concentration was rapidly attained with both compounds. After termination of the infusions, the concentration of 6-oxo-PGF1α declined according to a bi-exponential process. The steady-state plasma concentrations of 6-oxo-PGF1α obtained after infusion of 6-oxo-PGF1α and PGI2 were approximately 10 times higher than the corresponding steady-state level of PGF2α measured after infusion of PGF2α into the same dogs. The data presented suggest that PGI2 and 6-oxo-PGF1α are eliminated more slowly than PGF2α, probably because they are not taken up and metabolized in the lungs as rapidly as PGF2α.