PROTAMINES .3. SYNTHESIS OF THE TETRADECAPEPTIDE CORRESPONDING TO THE C-TERMINAL SEQUENCE 52-65 OF GALLINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 14  (2) , 143-152
Abstract
The synthesis of peptides containing blocks of arginyl residues is proposed through amidination of the corresponding ornithyl analogs. To test this strategy the ornithyl analog of the C-terminal sequence 52-65 galline was synthesized by the conventional method. The amidination reaction, performed on fragments of different length and ornithyl-residue content, quantitatively converts ornithines into arginines. The strategy proposed may represent a powerful tool for the synthesis of protamines and other basic proteins.

This publication has 1 reference indexed in Scilit:

  • Protamines
    Biochimica et Biophysica Acta (BBA) - Protein Structure, 1979