Indomethacin and the Patent Ductus Arteriosus

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Abstract
The patent ductus-indomethacin controversy continues almost unabated. I am not certain that my advice on this subject ("Don't rush to the drugstore, yet") in a previous Journal editorial1 has been heeded. I believe, though, that the level of healthy skepticism has generally risen, and I know that thoughtful studies in laboratories and neonatal nurseries have attempted to clarify the issues. The careful observations reported by Brash et al. in this issue2 contribute considerably to our understanding of how indomethacin closes the ductus, and in which preterm infants it does so.Brash et al. confirm the dependence of plasma indomethacin levels . . .