Antineoplastic Agents. 76. The Sea Urchin Strongylocentrotus droebachiensis
- 1 November 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 44 (6) , 701-704
- https://doi.org/10.1021/np50018a015
Abstract
An improved procedure based on centrifugation at 37,000 g was developed for isolating the antineoplastic glycoprotein strongylostatin 1 from S. droebachiensis. The green sea urchin also contains a 2nd protein anticancer constituent designated strongylostatin 2. Treatment of the murine P388 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.This publication has 7 references indexed in Scilit:
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