Lansoprazole Fast Disintegrating Tablet: A New Formulation for an Established Proton Pump Inhibitor
- 13 May 2003
- journal article
- review article
- Published by S. Karger AG in Digestion
- Vol. 67 (1-2) , 1-5
- https://doi.org/10.1159/000070393
Abstract
Lansoprazole is a proton pump inhibitor (PPI) which is an effective and well-tolerated treatment option in the management of acid-related disorders. Lansoprazole fast disintegrating tablet (LFDT) – a new, patient-friendly and more convenient formulation of lansoprazole which can be taken with or without water – is the first PPI to be made available as an orally disintegrating tablet. It represents an innovative drug delivery system, comprising enteric-coated microgranules of lansoprazole compressed with an inactive, rapidly dispersing matrix to form a tablet. When the tablet is placed on the tongue and sucked gently it disintegrates rapidly in the mouth, releasing the enteric-coated microgranules which are swallowed with the patient’s saliva without water. Alternatively, the tablet can be swallowed with a drink of water. Studies have shown that the bioavailability of LFDT is comparable to lansoprazole capsules, at both 15 and 30 mg doses; the indications and recommended dosages for LFDT are therefore identical to lansoprazole capsules. The new formulation may be of particular benefit to those with active life-styles who do not always have water available, patients who have difficulty in swallowing, and elderly patients.Keywords
This publication has 4 references indexed in Scilit:
- Comparative pharmacokinetics and safety of lansoprazole oral capsules and orally disintegrating tablets in healthy subjectsAlimentary Pharmacology & Therapeutics, 2003
- Lansoprazole for the Prevention of Recurrences of Ulcer Complications from Long-Term Low-Dose Aspirin UseNew England Journal of Medicine, 2002
- Growth Inhibitory and Bactericidal Activities of Lansoprazole Compared with Those of Omeprazole and Pantoprazole against Helicobacter pyloriHelicobacter, 1998
- The Effects of Oral Doses of Lansoprazole and Omeprazole on Gastric pHJournal of Clinical Gastroenterology, 1997