Hereditary Heinz-body Anaemia, Thrombocyttopenia, and Haemoglobinopathy (Hb Koln) in a Glasgow Family

Abstract
An abnormal hemo-globin (Hb Koln) has been observed in 10 members of a Glasgow family of remote German ancestry. Possession of this hemoglobin variant results in a form of hereditary Heinz-body anemia and thrombocytopenia. The clinical and laboratory findings in this family are presented and the characterization of the hemoglobin variant is described. The relationship of this variant to the hemolytic anemia, Heinz-body formation, and thrombocytopenia is discussed.