A NEW CONCEPT OF THE METABOLISM OF THE PATHOLOGICAL PROTEINS IN MYELOMATOSIS

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Abstract
The principal features of myelomatosis are the presence of abnormal globulins in the blood and of pathological cells resembling plasma cells in the bone marrow. Disappearance studies with patients' own and with normal adults' I-131 labelled albumin and globulins showed that the time was shortened for the disappearance of the pathological globulins in the patients, whereas that of all other fractions in the controls and in the patients was normal. Incubation studies have shown that the bone marrow plays some part in the breakdown of these pathological proteins and in one experiment there is suggestion that, in the disease, the liver may be involved in the synthesis of these abnormal globulins.