Effects of Various Additives on In Vitro Survival Time of Mouse Macrophages

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Abstract
Others have reported extensions of survival time of cultured cells due to additions of corticosteroids to the culture medium. in the present experiment, we investigated the effects on in vitro survival time of mouse macrophages of several compounds which are chemically unrelated to steroids but probably share with steroids the capacity to protect or stabilize cellular membranes. The number of cells viable after 15 days in culture exceeded control counts in macrophage cultures treated with butylated hydroxytoluene, sodium bisulfite, polyvinylpyrrolidone, and aspirin, at one or more concentrations. in contrast, sodium hypophosphite, 2-mercaptoethylamine, and alpha-tocopherol were not effective at the concentrations tested.

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