Genetic diversity ofAnaplasmaspecies major surface proteins and implications for anaplasmosis serodiagnosis and vaccine development

Abstract
The genusAnaplasma(Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity ofAnaplasmamajor surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity ofAnaplasmaspp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

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