Thyroxine Inactivation by Starvation in Cultured Hepatocarcinoma Cells. Formation of Reverse Triiodothyronine
- 1 November 1978
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 10 (06) , 528-531
- https://doi.org/10.1055/s-0028-1093385
Abstract
The effect of starvation on thyroid hormone metabolism was studied in monkey hepatocarcinoma monolayer cultures. Nonphenolic ring monodeiodination of thyroxine, 3, 5, 3'-triiodothyronine and 3, 3'-diiodothyronine was accelerated. Since phenolic ring deiodination of 3, 3', 5'-triiodothyronine (reverse T3) was unaffected, this metabolite accumulated in the medium during thyroxine metabolism. This suggests that increased serum reverse T3 in malnourished humans may be caused by enhanced deiodination of thyroxine rather than decreased rT3 catabolism.Keywords
This publication has 1 reference indexed in Scilit:
- Metabolism of thyroid hormones by cultured monkey hepatocarcinoma cells. Nonphenolic ring dieodination and sulfation.Journal of Biological Chemistry, 1977