On the Metabolism of Coprostane-3 alpha, 7 alpha-diol in Mouse Liver Homogenates. Bile Acids and Steroids 130.

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Abstract
Mouse liver mitochondria were found to oxidize tritium labeled coprostane-3[alpha], 7[alpha]-diol to coprostane-3[alpha], 7[alpha], 26-triol. Fortification of the mito-chondrial preparations with 100 000 X g supernatant fluid of mouse liver homogenate resulted in the additional formation of smaller amounts of one unknown neutral sterol and of steroid acids. Tritium labeled coprostane-3[alpha], 7[alpha], 26-triol was metabolized by the bile fistula rat mainly into chenodeoxycholic acid and 2 compounds with chromatographic properties as those of the two 6[beta]-hydroxylated metabolites of chenodeoxycholic acid, while cholic acid was a minor metabolite.