Aortic valve replacement with frozen irradiated homografts An 18-year experience

1 January 1989

journal article
Published by Oxford University Press (OUP) in European Journal of Cardio-Thoracic Surgery

Vol. 3 (6) , 558-561
https://doi.org/10.1016/1010-7940(89)90119-x

Abstract

Between May 1968 and April 1981, 339 patients underwent isolated aorticvalve replacement using frozen irradiated homografts. All the operationswere carried out by the same surgeon (EJMW) using the same technique.Thirty-two patients were lost to follow-up at various stages and thelong-term results of the remaining 307 patients are reported. Two hundredand thirty-four were males and 73 females. Their ages ranged between 10 and75 years, with a mean age of 53. The dominant lesion was aortic stenosis in195 cases (63.5%), aortic regurgitation in 68 (22.1%), and mixed aorticvalve disease in 44 (14.3%). Early mortality was 8.8% and late mortalityduring the 5-18 year follow-up period was 49.6%. Re-operations forhomograft failure were carried out in 112 patients (40%), with an earlymortality of 25%. The results are compared with those of other major seriesusing antibiotic sterilized homograft valves.

Keywords

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