COMPONENTS OF VITREOUS-SOLUBLE PROTEINS - EFFECT OF HYPEROXIA AND AGE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (3) , 228-232
Abstract
In young puppies, the retina, which was incompletely vascularized at birth became fully vascularized at approximately 4 wk of age. During this period of vessel growth the total content of vitreous-soluble protein was closely associated with the rate of retinal vessel growth. As vascularization progressed toward completion, the protein originally present at birth decreased to a negligible or undetected amount. Intravitreal neovascularization was produced in young puppies by exposure to 85% O2 for 4 days, then removal to room air. This form of neovascularization resembled closely that observed in human proliferative diabetic retinopathy. The O2 treatment, which initially produced retinal capillary closure, then neovascularization, was associated with a retention of vitreous-soluble protein at a high level for several days. The vitreous protein(s) may be fundamentally involved in the process of normal vascularization of the retina and in retinal neovascularization.

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