Studies on the kinetics of haemolytic systems

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Abstract
In a study of the rate at which a lysin such as saponin was used up during stromatolysis (breaking down of the red cell envelopes, which followed hemolysis), it was shown that the equations which have hitherto been used to describe the using up of lysin during hemolysis are not applicable to the subsequent process. The principal conclusions were: (a) that the reaction between cells and lysin is characterized by peculiar equilibrium conditions, in which using up of lysin ceases while there is still free in the system a quantity of lysin which is nearly linear with the amount initially present, (b) that the course of the disappearance of lysin is probably described by an equation, the exact form of which could not be defined, in which there is a velocity constant which Undergoes continual decrease as the reaction proceeds, (c) that such a decrease in the velocity constant is probably responsible for the introductions of an arbitrary constant n into the existing equations for the kinetics of hemolysis, and (d) that although these existing equations are probably only formal ones, the conclusions based on the existing analysis of time-dilution and % hemolysis curves are themselves essentially unchanged.

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