Interaction of 5α,6α-cholesterol oxide with DNA and other nucleophiles
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 420-421
- https://doi.org/10.1039/c39790000420
Abstract
5α,6α-Cholesterol oxide forms a strong physical complex with DNA which, on incubation, leads to a significant amount of covalent attachment of steroid to DNA; both this oxide and its 3-acetate give adducts with neutral thiols and heterocyclic amines, the former alone responding to acidic catalysis.Keywords
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