Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease
- 15 February 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 227 (4688) , 770-773
- https://doi.org/10.1126/science.3155875
Abstract
Golgi impregnations of neostriatum from deceased Huntington's disease patients and controls were examined. In all cases of Huntington's disease the morphology of dendrites of medium-sized spiny neurons was markedly altered by the appearance of recurved endings and appendages, a decrease or increase in the density of spines, and abnormalities in the size and shape of spines. Pathological changes were rarely observed in medium-sized and large aspiny neostriatal neurons. The findings provide evidence for simultaneous degeneration and growth of spiny neurons in Huntington's disease and support the view that a specific population of neostriatal neurons is selectively involved in its pathogenesis.This publication has 23 references indexed in Scilit:
- A Golgi study of the human neostriatum: Neurons and afferent fibersJournal of Comparative Neurology, 1985
- Localization of substance P-like immunoreactivity in neurons and nerve terminals in the neostriatum of the rat: a correlated light and electron microscopic studyJournal of Neurocytology, 1983
- Morphometric analysis of granule cell dendrites in the mouse dentate gyrusJournal of Comparative Neurology, 1983
- Dendritic reorganization in the denervated dentate gyrus of the rat following entorhinal cortical lesions: A Golgi and electron microscopic analysisJournal of Comparative Neurology, 1983
- Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the golgi‐peroxidase transport‐degeneration procedureJournal of Comparative Neurology, 1981
- Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidaseJournal of Comparative Neurology, 1980
- Ultrastructure of Golgi-impregnated and gold-toned spiny and aspiny neurons in the monkey neostriatumJournal of Neurocytology, 1980
- The GABA Neurons and their axon terminals in rat corpus striatum as demonstrated by GAD immunocytochemistryJournal of Comparative Neurology, 1979
- Spine Loss and Regrowth in Hippocampus following DeafferentationNature, 1974
- The site of termination of afferent fibres in the caudate nucleusPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1971