IgA Nephropathy

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Abstract
In the great majority of cases, IgAN is an isolated renal disease with no apparent clinical antecedent or association—primary IgAN. As well as the association with IgA-mediated systemic vasculitis in HSP, there are a number of other clinical contexts that seem to predispose to IgAN, usually called secondary IgAN. Among the best characterized associations are those with rheumatoid arthritis, ankylosing spondylitis, and Reiter's syndrome; celiac disease and dermatitis herpetiformis; chronic liver disease (especially alcohol induced); and viral diseases, particularly HIV infection and hepatitis B (in endemic areas). However, caution should be exercised in interpreting some other associations as causal. There are many anecdotal reports of single cases that may reflect merely chance associations with a disease as common as IgAN.

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