THE HEMATOLOGIC RESPONSE IN DOGS TO THE ADMINISTRATION OF ANTI SPLEEN SERUM
Open Access
- 1 March 1947
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 2 (2) , 175-184
- https://doi.org/10.1182/blood.v2.2.175.175
Abstract
1. Intravenous injection into dogs of rabbit anti-dog-spleen serum in doses of 0.04 cc./10 Kg. results in a significant increase in the mononuclear cells of the peripheral blood. 2. The rise in circulating mononuclears occurs promptly, with 24-48 hours, and is sustained, generally for 20 days. 3. A large dose of the same serum, 5.4 cc./10 Kg., exerted an opposite effect, poducing a significant decrease in circulating mononuclears. 4. The possible significance of these findings is discussed.Keywords
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