[(3-Dimethylamino)propyl]dimethylaluminum: A Convenient Reagent for Methylation and Ethynylation of Carbonyl Compounds
- 1 September 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (09) , 1127-1130
- https://doi.org/10.1055/s-1996-4334
Abstract
At 60-80°C the title compound methylates a variety of mono- and diketones. Aromatic aldehydes undergo simple methylation by the reagent only after initial treatment with an equivalent amount of AlCl3. Upon reaction of Me2Al(CH2)3NMe2 with terminal acetylenes the aluminum complex is converted into a carbonyl-alkynylation reagent.Keywords
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