Prospects for Hyperthermia in Human Cancer Therapy

Abstract
Systemic hyperthermia in man may occur by accident, as in heat stroke or malignant hyperthermia during general anesthesia, or it may be therapeutically induced (fever therapy). The latter was used infrequently since the advent of antibiotics, except recently for treatment of cancer. Local or regional heating combined with X-irradiation for human cancer therapy was sporadically reported for over 60 yr, but has not found its place in clinical medicine possibly due to technical limitations in heat production and dosimetry. Preliminary results are reported for treatment of spontaneous animal tumors with radiofrequency current fields and X-irradiation.