Action of diethixime, a new cholinesterase reactivator, on the central nervous system

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Abstract
A new cholinesterase reactivator, p-bromobenzoylthiohydroximic acid S-diethylaminoethyl ester hydrochloride (diethixime, containing a tertiary nitrogen atom in its molecule), in a dose of 20 mg/kg (0.02 LD50), unlike dipyroxime (containing a quaternary nitrogen atom), in a dose of 3 mg/kg (0.02 LD50), was shown to have a central action on rats and rabbits poisoned with dimethyldichlorovinyl phosphate. This was shown by restoration of acetylcholinesterase activity in various parts of the rabbits' brains and normalization of the electroencephalogram and of the functional state of the spinal motoneurons of the rats.