Activity of protein kinase C in erythrocytes in primary hypertension
- 1 November 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 6 (11) , 853-857
- https://doi.org/10.1097/00004872-198811000-00002
Abstract
The activity of protein kinase C and A was studied in the erythrocytes of patients with essential hypertension (EH) and in spontaneously hypertensive rats (SHR, Okamoto—Aoki strain). Protein kinase C activity was also studied in the erythrocytes of patients with hypertension of renal origin. Protein kinase C activity in the lysate of erythrocytes of patients with EH and in SHR was found to be increased 1.6–2.0-fold as compared to that in normotensive controls. No notable differences in protein kinase A activity were observed between hypertensive and normotensive groups. In erythrocytes of patients with renal hypertension, no notable changes in protein kinase C activity were revealed.Keywords
This publication has 19 references indexed in Scilit:
- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.Published by Elsevier ,2021
- Red blood cell abnormalities and spontaneous hypertension in the rat. A genetically determined link.Hypertension, 1985
- Strain differences among inbred mice in protein kinase C activityBiochemical and Biophysical Research Communications, 1984
- Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.Journal of Biological Chemistry, 1982
- Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.Proceedings of the National Academy of Sciences, 1980
- Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombinBiochemical and Biophysical Research Communications, 1980
- A NEW TEST SHOWING ABNORMAL NET Na+ AND K+ FLUXES IN ERYTHROCYTES OF ESSENTIAL HYPERTENSIVE PATIENTSThe Lancet, 1979
- Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.Journal of Biological Chemistry, 1977
- A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counterAnalytical Biochemistry, 1960
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951